Gene description for CACNA1E
Gene name calcium channel, voltage-dependent, R type, alpha 1E subunit
Gene symbol CACNA1E
Other names/aliases BII
CACH6
CACNL1A6
Cav2.3
Species Homo sapiens
 Database cross references - CACNA1E
ExoCarta ExoCarta_777
Vesiclepedia VP_777
Entrez Gene 777
HGNC 1392
MIM 601013
UniProt Q15878  
 CACNA1E identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CACNA1E
Molecular Function
    voltage-gated calcium channel activity GO:0005245 IDA
    voltage-gated calcium channel activity GO:0005245 IMP
    calcium ion binding GO:0005509 IEA
    high voltage-gated calcium channel activity GO:0008331 IBA
    voltage-gated monoatomic cation channel activity GO:0022843 IDA
Biological Process
    chemical synaptic transmission GO:0007268 IBA
    calcium ion import across plasma membrane GO:0098703 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    voltage-gated calcium channel complex GO:0005891 IBA
    neuronal cell body GO:0043025 IBA
    synapse GO:0045202 IEA
 Experiment description of studies that identified CACNA1E in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CACNA1E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFHC1  
Affinity Capture-Western Homo sapiens
2 GNB2 2783
Affinity Capture-Western Homo sapiens
3 TRIM21 6737
Affinity Capture-MS Homo sapiens
4 PSMD1 5707
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml



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