Gene description for MT1M
Gene name metallothionein 1M
Gene symbol MT1M
Other names/aliases MT-1M
MT-IM
MT1
MT1K
Species Homo sapiens
 Database cross references - MT1M
ExoCarta ExoCarta_4499
Vesiclepedia VP_4499
Entrez Gene 4499
HGNC 14296
MIM 156357
UniProt Q8N339  
 MT1M identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MT1M
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISS
    metal ion binding GO:0046872 IBA
Biological Process
    intracellular zinc ion homeostasis GO:0006882 IBA
    detoxification of copper ion GO:0010273 IBA
    negative regulation of growth GO:0045926 ISS
    cellular response to cadmium ion GO:0071276 IBA
    cellular response to copper ion GO:0071280 IBA
    cellular response to zinc ion GO:0071294 IBA
    cellular response to zinc ion GO:0071294 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified MT1M in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MT1M
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PGP 283871
Affinity Capture-MS Homo sapiens
2 NEFH 4744
Affinity Capture-MS Homo sapiens
3 KRTAP17-1  
Two-hybrid Homo sapiens
4 TPPP2  
Affinity Capture-MS Homo sapiens
5 CYSRT1 375791
Two-hybrid Homo sapiens
6 UFL1 23376
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
7 MT1E 4493
Affinity Capture-MS Homo sapiens
8 RELB  
Two-hybrid Homo sapiens
9 UBA52 7311
Affinity Capture-MS Homo sapiens
10 KRTAP5-1  
Two-hybrid Homo sapiens
11 KRTAP5-9  
Two-hybrid Homo sapiens
12 TRIM21 6737
Affinity Capture-MS Homo sapiens
13 SMCP  
Two-hybrid Homo sapiens
14 MT1G 4495
Affinity Capture-MS Homo sapiens
15 DDIT4L  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MT1M is involved
PathwayEvidenceSource
Cellular responses to stimuli IEA Reactome
Metallothioneins bind metals IEA Reactome
Response to metal ions IEA Reactome





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