Gene description for MMRN2
Gene name multimerin 2
Gene symbol MMRN2
Other names/aliases EMILIN-3
EMILIN3
ENDOGLYX-1
Species Homo sapiens
 Database cross references - MMRN2
ExoCarta ExoCarta_79812
Entrez Gene 79812
HGNC 19888
MIM 608925
UniProt Q9H8L6  
 MMRN2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for MMRN2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IDA
    angiogenesis GO:0001525 IEA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    basement membrane GO:0005604 IEA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified MMRN2 in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMRN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MMRN2 is involved
No pathways found





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