Gene description for ZBTB4
Gene name zinc finger and BTB domain containing 4
Gene symbol ZBTB4
Other names/aliases KAISO-L1
ZNF903
Species Homo sapiens
 Database cross references - ZBTB4
ExoCarta ExoCarta_57659
Entrez Gene 57659
HGNC 23847
MIM 612308
UniProt Q9P1Z0  
 ZBTB4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ZBTB4
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    methyl-CpG binding GO:0008327 IDA
    methyl-CpNpG binding GO:0010428 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 IDA
    sequence-specific DNA binding GO:0043565 IDA
    protein kinase binding GO:0019901 IPI
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    cellular response to DNA damage stimulus GO:0006974 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified ZBTB4 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ZBTB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZBTB4 is involved
No pathways found





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