Gene description for KATNAL2
Gene name katanin p60 subunit A-like 2
Gene symbol KATNAL2
Other names/aliases -
Species Homo sapiens
 Database cross references - KATNAL2
ExoCarta ExoCarta_83473
Entrez Gene 83473
HGNC 25387
MIM 614697
UniProt Q8IYT4  
 KATNAL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KATNAL2
Molecular Function
    microtubule binding GO:0008017 IEA
    microtubule-severing ATPase activity GO:0008568 IBA
    ATP binding GO:0005524 IEA
Biological Process
    metabolic process GO:0008152 IEA
    microtubule severing GO:0051013 IEA
    cytoplasmic microtubule organization GO:0031122 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 IEA
 Experiment description of studies that identified KATNAL2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KATNAL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KATNAL2 is involved
No pathways found

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