Gene description for GPT
Gene name glutamic-pyruvate transaminase (alanine aminotransferase)
Gene symbol GPT
Other names/aliases AAT1
ALT1
GPT1
Species Homo sapiens
 Database cross references - GPT
ExoCarta ExoCarta_2875
Entrez Gene 2875
HGNC 4552
MIM 138200
UniProt P24298  
 GPT identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GPT
Molecular Function
    L-alanine:2-oxoglutarate aminotransferase activity GO:0004021 NAS
    pyridoxal phosphate binding GO:0030170 IEA
Biological Process
    cellular nitrogen compound metabolic process GO:0034641 TAS
    cellular amino acid biosynthetic process GO:0008652 TAS
    small molecule metabolic process GO:0044281 TAS
    L-alanine catabolic process GO:0042853 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified GPT in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GPT
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GPT is involved
PathwayEvidenceSource
Amino acid synthesis and interconversion (transamination) TAS Reactome





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