Gene description for CCDC134
Gene name coiled-coil domain containing 134
Gene symbol CCDC134
Other names/aliases -
Species Homo sapiens
 Database cross references - CCDC134
ExoCarta ExoCarta_79879
Vesiclepedia VP_79879
Entrez Gene 79879
HGNC 26185
UniProt Q9H6E4  
 CCDC134 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CCDC134
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    angiogenesis GO:0001525 IEA
    placenta development GO:0001890 IEA
    ventricular system development GO:0021591 IEA
    regulation of ossification GO:0030278 IMP
    embryonic hemopoiesis GO:0035162 IEA
    embryonic liver development GO:1990402 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified CCDC134 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CCDC134
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MOV10 4343
Affinity Capture-RNA Homo sapiens
2 LRRC59 55379
Proximity Label-MS Homo sapiens
3 MOCS2  
Co-fractionation Homo sapiens
4 YWHAZ 7534
Affinity Capture-MS Homo sapiens
5 UBQLN4 56893
Two-hybrid Homo sapiens
6 UBC 7316
Affinity Capture-MS Homo sapiens
7 RPA2 6118
Proximity Label-MS Homo sapiens
8 VCP 7415
Affinity Capture-MS Homo sapiens
9 SEC61B 10952
Proximity Label-MS Homo sapiens
10 CALR3  
Proximity Label-MS Homo sapiens
11 RPA3 6119
Proximity Label-MS Homo sapiens
12 PDIA4 9601
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CCDC134 is involved
No pathways found





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