Gene description for CXXC4
Gene name CXXC finger protein 4
Gene symbol CXXC4
Other names/aliases IDAX
Species Homo sapiens
 Database cross references - CXXC4
ExoCarta ExoCarta_80319
Entrez Gene 80319
HGNC 24593
MIM 611645
 CXXC4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CXXC4
Molecular Function
    DNA binding GO:0003677 IEA
    zinc ion binding GO:0008270 IEA
    PDZ domain binding GO:0030165 IPI
Biological Process
    zygotic specification of dorsal/ventral axis GO:0007352 ISS
    negative regulation of Wnt signaling pathway GO:0030178 IDA
    Wnt signaling pathway GO:0016055 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified CXXC4 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CXXC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CXXC4 is involved
No pathways found





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