Gene description for Rnf130
Gene name ring finger protein 130
Gene symbol Rnf130
Other names/aliases 2510042A13Rik
G1RZFP
G1rp
GOLIATH
GP
Species Mus musculus
 Database cross references - Rnf130
ExoCarta ExoCarta_59044
Entrez Gene 59044
UniProt Q8VEM1  
 Rnf130 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rnf130
Molecular Function
    protein-glycine ligase activity GO:0070735 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    ubiquitin-protein transferase activity GO:0004842 ISO
    protein-glycine ligase activity, initiating GO:0070736 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    ligase activity GO:0016874 IEA
    metal ion binding GO:0046872 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    zinc ion binding GO:0008270 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
Biological Process
    apoptotic process GO:0006915 IEA
    programmed cell death GO:0012501 IMP
    protein ubiquitination GO:0016567 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    membrane GO:0016020 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 NAS
 Experiment description of studies that identified Rnf130 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rnf130
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFBR1  
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml
 Pathways in which Rnf130 is involved
No pathways found





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