Gene description for Ubb
Gene name ubiquitin B
Gene symbol Ubb
Other names/aliases AL033289
Rps27a
Uba52
Ubb2
Ubc
Species Mus musculus
 Database cross references - Ubb
ExoCarta ExoCarta_22187
Entrez Gene 22187
UniProt P0CG49  
 Ubb identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Pancreatic cells 19351151    
 Gene ontology annotations for Ubb
Biological Process
    energy homeostasis GO:0097009 IMP
    seminiferous tubule development GO:0072520 IMP
    fat pad development GO:0060613 IMP
    female meiosis I GO:0007144 IMP
    male meiosis I GO:0007141 IMP
    hypothalamus gonadotrophin-releasing hormone neuron development GO:0021888 IMP
    regulation of mitochondrial membrane potential GO:0051881 ISO
    neuron projection morphogenesis GO:0048812 ISO
    male gonad development GO:0008584 IMP
    ubiquitin homeostasis GO:0010992 IMP
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    regulation of neuron death GO:1901214 ISO
    adipose tissue development GO:0060612 IMP
    mitochondrion transport along microtubule GO:0047497 ISO
    female gonad development GO:0008585 IMP
    positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 ISO
Subcellular Localization
    neuron projection GO:0043005 ISO
    mitochondrion GO:0005739 ISO
    neuronal cell body GO:0043025 ISO
    cell GO:0005623 IGI
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Ubb in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ubb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMAD4  
Affinity Capture-Luminescence Homo sapiens
2 TGFBR1  
Affinity Capture-Luminescence Homo sapiens
3 SMURF1 57154
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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