Gene description for Bmpr2
Gene name	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene symbol	Bmpr2
Other names/aliases	2610024H22Rik AL117858 AW546137 BB189135 BMP-2 BMPR-2 BMPR-II BMPRII BRK-3 Gm20272
Species	Mus musculus
Database cross references - Bmpr2
ExoCarta	ExoCarta_12168
Vesiclepedia	VP_12168
Entrez Gene	12168
UniProt	O35607
Bmpr2 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Bmpr2

Molecular Function     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 IMP     transforming growth factor beta receptor activity GO:0005024 IBA     transforming growth factor beta receptor activity, type I GO:0005025 IEA     transforming growth factor beta receptor activity, type II GO:0005026 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     activin receptor activity, type I GO:0016361 IEA     activin receptor activity, type II GO:0016362 IEA     activin receptor activity, type II GO:0016362 ISO     growth factor binding GO:0019838 IEA     growth factor binding GO:0019838 ISO     BMP binding GO:0036122 IDA     BMP binding GO:0036122 ISO     cadherin binding GO:0045296 IEA     cadherin binding GO:0045296 ISO     metal ion binding GO:0046872 IEA     transforming growth factor beta receptor activity, type III GO:0070123 IEA     BMP receptor activity GO:0098821 IDA     BMP receptor activity GO:0098821 IMP     protein tyrosine kinase binding GO:1990782 IEA     protein tyrosine kinase binding GO:1990782 ISO Biological Process     blood vessel development GO:0001568 IBA     osteoblast differentiation GO:0001649 IDA     osteoblast differentiation GO:0001649 ISO     mesoderm formation GO:0001707 IMP     maternal placenta development GO:0001893 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     endothelial cell proliferation GO:0001935 IEA     endothelial cell proliferation GO:0001935 ISO     lymphangiogenesis GO:0001946 IMP     blood vessel remodeling GO:0001974 IMP     chondrocyte development GO:0002063 IEA     chondrocyte development GO:0002063 ISO     negative regulation of systemic arterial blood pressure GO:0003085 IEA     negative regulation of systemic arterial blood pressure GO:0003085 ISO     outflow tract septum morphogenesis GO:0003148 IMP     outflow tract septum morphogenesis GO:0003148 IMP     outflow tract morphogenesis GO:0003151 IMP     aortic valve development GO:0003176 IMP     pulmonary valve development GO:0003177 IMP     atrioventricular valve morphogenesis GO:0003181 IMP     mitral valve morphogenesis GO:0003183 IMP     tricuspid valve morphogenesis GO:0003186 IMP     endocardial cushion development GO:0003197 IMP     negative regulation of cell proliferation involved in heart valve morphogenesis GO:0003252 IMP     cell surface receptor protein serine/threonine kinase signaling pathway GO:0007178 ISO     cellular response to starvation GO:0009267 IEA     anterior/posterior pattern specification GO:0009952 IGI     anterior/posterior pattern specification GO:0009952 IMP     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     positive regulation of epithelial cell migration GO:0010634 IEA     positive regulation of epithelial cell migration GO:0010634 ISO     regulation of lung blood pressure GO:0014916 IMP     regulation of lung blood pressure GO:0014916 ISO     proteoglycan biosynthetic process GO:0030166 ISS     negative regulation of cell growth GO:0030308 IEA     negative regulation of cell growth GO:0030308 ISO     positive regulation of bone mineralization GO:0030501 IEA     positive regulation of bone mineralization GO:0030501 ISO     BMP signaling pathway GO:0030509 IBA     BMP signaling pathway GO:0030509 IDA     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway GO:0030509 ISO     BMP signaling pathway GO:0030509 ISO     activin receptor signaling pathway GO:0032924 IEA     regulation of cell population proliferation GO:0042127 ISO     positive regulation of osteoblast differentiation GO:0045669 IEA     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of ossification GO:0045778 IMP     negative regulation of vasoconstriction GO:0045906 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     lung alveolus development GO:0048286 IMP     negative regulation of smooth muscle cell proliferation GO:0048662 IEA     negative regulation of smooth muscle cell proliferation GO:0048662 ISO     cardiac muscle tissue development GO:0048738 IMP     positive regulation of axon extension involved in axon guidance GO:0048842 IMP     stem cell differentiation GO:0048863 NAS     negative regulation of muscle cell differentiation GO:0051148 IDA     limb development GO:0060173 IGI     endochondral bone morphogenesis GO:0060350 ISS     positive regulation of SMAD protein signal transduction GO:0060391 IEA     positive regulation of SMAD protein signal transduction GO:0060391 ISO     positive regulation of SMAD protein signal transduction GO:0060391 ISO     ventricular septum morphogenesis GO:0060412 IMP     atrial septum morphogenesis GO:0060413 IMP     lung vasculature development GO:0060426 IEA     lung vasculature development GO:0060426 ISO     lymphatic endothelial cell differentiation GO:0060836 IMP     artery development GO:0060840 IMP     venous blood vessel development GO:0060841 IMP     positive regulation of cartilage development GO:0061036 ISS     retina vasculature development in camera-type eye GO:0061298 IMP     pharyngeal arch artery morphogenesis GO:0061626 IMP     pharyngeal arch artery morphogenesis GO:0061626 IMP     cellular response to growth factor stimulus GO:0071363 IBA     cellular response to BMP stimulus GO:0071773 ISO     endothelial cell apoptotic process GO:0072577 IEA     endothelial cell apoptotic process GO:0072577 ISO     negative regulation of chondrocyte proliferation GO:1902731 IEA     negative regulation of chondrocyte proliferation GO:1902731 ISO     semi-lunar valve development GO:1905314 IMP Subcellular Localization     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     caveola GO:0005901 IEA     caveola GO:0005901 ISO     caveola GO:0005901 ISO     clathrin-coated pit GO:0005905 IDA     adherens junction GO:0005912 IEA     adherens junction GO:0005912 ISO     basal plasma membrane GO:0009925 IEA     basal plasma membrane GO:0009925 ISO     cell surface GO:0009986 IDA     postsynaptic density GO:0014069 IDA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     axon GO:0030424 IDA     dendrite GO:0030425 IDA     dendrite GO:0030425 ISO     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     receptor complex GO:0043235 IBA     cell body GO:0044297 IDA     plasma membrane region GO:0098590 IDA