Gene description for FTCD
Gene name formimidoyltransferase cyclodeaminase
Gene symbol FTCD
Other names/aliases LCHC1
Species Homo sapiens
 Database cross references - FTCD
ExoCarta ExoCarta_10841
Entrez Gene 10841
HGNC 3974
MIM 606806
UniProt O95954  
 FTCD identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FTCD
Molecular Function
    protein binding GO:0005515 IPI
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 EXP
    glutamate formimidoyltransferase activity GO:0030409 IEA
    folic acid binding GO:0005542 IEA
Biological Process
    tetrahydrofolate interconversion GO:0035999 IEA
    histidine catabolic process to glutamate and formamide GO:0019556 IEA
    small molecule metabolic process GO:0044281 TAS
    histidine catabolic process GO:0006548 TAS
    cytoskeleton organization GO:0007010 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    folic acid-containing compound metabolic process GO:0006760 TAS
    histidine catabolic process to glutamate and formate GO:0019557 IEA
Subcellular Localization
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 TAS
    centriole GO:0005814 IEA
    Golgi apparatus GO:0005794 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified FTCD in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FTCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FTCD is involved
PathwayEvidenceSource
Histidine catabolism TAS Reactome





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