Gene description for SIGLEC1
Gene name sialic acid binding Ig-like lectin 1, sialoadhesin
Gene symbol SIGLEC1
Other names/aliases CD169
Species Homo sapiens
 Database cross references - SIGLEC1
ExoCarta ExoCarta_6614
Entrez Gene 6614
HGNC 11127
MIM 600751
UniProt Q9BZZ2  
 SIGLEC1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SIGLEC1
Molecular Function
    carbohydrate binding GO:0030246 NAS
Biological Process
    positive regulation of T cell apoptotic process GO:0070234 IEA
    single organismal cell-cell adhesion GO:0016337 NAS
    endocytosis GO:0006897 IEA
    inflammatory response GO:0006954 NAS
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IEA
    cell-matrix adhesion GO:0007160 NAS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 NAS
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified SIGLEC1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SIGLEC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPN 6693
Invivo Homo sapiens
2 TNR  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SIGLEC1 is involved
No pathways found

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