Gene description for CLTB
Gene name clathrin, light chain B
Gene symbol CLTB
Other names/aliases CLTLB
Species Bos taurus
 Database cross references - CLTB
ExoCarta ExoCarta_281698
Vesiclepedia VP_281698
Entrez Gene 281698
UniProt P04975  
 CLTB identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CLTB
Molecular Function
    structural molecule activity GO:0005198 IEA
    clathrin heavy chain binding GO:0032050 IEA
Biological Process
    intracellular protein transport GO:0006886 IEA
    clathrin coat assembly GO:0048268 IEA
    clathrin-dependent endocytosis GO:0072583 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    clathrin coat of trans-Golgi network vesicle GO:0030130 IEA
    clathrin coat of coated pit GO:0030132 IEA
    synaptic vesicle membrane GO:0030672 IEA
    postsynaptic endocytic zone cytoplasmic component GO:0099631 IEA
 Experiment description of studies that identified CLTB in exosomes
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLTB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hip1r  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
2 HIP1 3092
Two-hybrid Homo sapiens
3 CLTC  
Reconstituted Complex Bos taurus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here