Gene description for GRID1
Gene name glutamate receptor, ionotropic, delta 1
Gene symbol GRID1
Other names/aliases GluD1
Species Homo sapiens
 Database cross references - GRID1
ExoCarta ExoCarta_2894
Entrez Gene 2894
HGNC 4575
MIM 610659
UniProt Q9ULK0  
 GRID1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for GRID1
Molecular Function
    ionotropic glutamate receptor activity GO:0004970 IBA
    extracellular-glutamate-gated ion channel activity GO:0005234 IBA
Biological Process
    ionotropic glutamate receptor signaling pathway GO:0035235 IBA
    social behavior GO:0035176 ISS
    ion transmembrane transport GO:0034220 IBA
    synaptic transmission, glutamatergic GO:0035249 IBA
Subcellular Localization
    cell junction GO:0030054 IEA
    dendrite GO:0030425 IBA
    ionotropic glutamate receptor complex GO:0008328 IBA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 IBA
    postsynaptic membrane GO:0045211 IBA
 Experiment description of studies that identified GRID1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GRID1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GRID1 is involved
No pathways found





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