Gene description for CPPED1
Gene name calcineurin-like phosphoesterase domain containing 1
Gene symbol CPPED1
Other names/aliases CSTP1
Species Homo sapiens
 Database cross references - CPPED1
ExoCarta ExoCarta_55313
Vesiclepedia VP_55313
Entrez Gene 55313
HGNC 25632
MIM 615603
UniProt Q9BRF8  
 CPPED1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CPPED1
Molecular Function
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    azurophil granule lumen GO:0035578 TAS
 Experiment description of studies that identified CPPED1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPPED1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PFKM 5213
Co-fractionation Homo sapiens
2 ALDH1B1 219
Co-fractionation Homo sapiens
3 C10orf88  
Affinity Capture-MS Homo sapiens
4 NARS 4677
Affinity Capture-MS Homo sapiens
5 PRDX3 10935
Co-fractionation Homo sapiens
6 PICALM 8301
Co-fractionation Homo sapiens
7 SEPSECS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 POT1  
Two-hybrid Homo sapiens
9 ASPM 259266
Negative Genetic Homo sapiens
10 MCM2 4171
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CPPED1 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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