Gene description for REG4
Gene name regenerating islet-derived family, member 4
Gene symbol REG4
Other names/aliases GISP
REG-IV
RELP
Species Homo sapiens
 Database cross references - REG4
ExoCarta ExoCarta_83998
Entrez Gene 83998
HGNC 22977
MIM 609846
UniProt Q9BYZ8  
 REG4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 17956143    
 Gene ontology annotations for REG4
Molecular Function
    mannan binding GO:2001065 IDA
    heparin binding GO:0008201 IDA
    calcium ion binding GO:0005509 IDA
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified REG4 in exosomes
1
Experiment ID 20
ISEV standards
EM
EV Biophysical techniques
HSP90
EV Cytosolic markers
CD63|CD81|LAMP1
EV Membrane markers
GOLGA2|cytochrome c
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for REG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which REG4 is involved
No pathways found





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