Gene description for REG4
Gene name regenerating islet-derived family, member 4
Gene symbol REG4
Other names/aliases GISP
REG-IV
RELP
Species Homo sapiens
 Database cross references - REG4
ExoCarta ExoCarta_83998
Vesiclepedia VP_83998
Entrez Gene 83998
HGNC 22977
MIM 609846
UniProt Q9BYZ8  
 REG4 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 17956143    
 Gene ontology annotations for REG4
Molecular Function
    calcium ion binding GO:0005509 IDA
    heparin binding GO:0008201 IDA
    signaling receptor activity GO:0038023 IBA
    mannan binding GO:2001065 IBA
    mannan binding GO:2001065 IDA
Biological Process
    response to bacterium GO:0009617 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified REG4 in sEVs
1
Experiment ID 20
MISEV standards
EM
Biophysical techniques
HSP90|CD63|CD81|LAMP1
Enriched markers
GOLGA2|cytochrome c
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for REG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL22 84861
Affinity Capture-MS Homo sapiens
2 KLHL26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RNF123 63891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBAC1 10422
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SIRT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PITRM1 10531
Affinity Capture-MS Homo sapiens
7 HTRA1 5654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ATE1 11101
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which REG4 is involved
No pathways found





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