Gene description for CYB5R2
Gene name cytochrome b5 reductase 2
Gene symbol CYB5R2
Other names/aliases B5R.2
Species Homo sapiens
 Database cross references - CYB5R2
ExoCarta ExoCarta_51700
Vesiclepedia VP_51700
Entrez Gene 51700
HGNC 24376
MIM 608342
UniProt Q6BCY4  
 CYB5R2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CYB5R2
Molecular Function
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IDA
    protein binding GO:0005515 IPI
Biological Process
    sterol biosynthetic process GO:0016126 IEA
    oxidation-reduction process GO:0055114 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    membrane GO:0016020 IDA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified CYB5R2 in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CYB5R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CYB5R2 is involved
No pathways found





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