Gene description for CYB5R2
Gene name cytochrome b5 reductase 2
Gene symbol CYB5R2
Other names/aliases B5R.2
Species Homo sapiens
 Database cross references - CYB5R2
ExoCarta ExoCarta_51700
Entrez Gene 51700
HGNC 24376
MIM 608342
UniProt Q6BCY4  
 CYB5R2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CYB5R2
Molecular Function
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IDA
    protein binding GO:0005515 IPI
Biological Process
    sterol biosynthetic process GO:0016126 IEA
    oxidation-reduction process GO:0055114 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    membrane GO:0016020 IDA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified CYB5R2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CYB5R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CYB5R2 is involved
No pathways found

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