Gene description for MGLL
Gene name monoglyceride lipase
Gene symbol MGLL
Other names/aliases HU-K5
HUK5
MAGL
MGL
Species Homo sapiens
 Database cross references - MGLL
ExoCarta ExoCarta_11343
Entrez Gene 11343
HGNC 17038
MIM 609699
UniProt Q99685  
 MGLL identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for MGLL
Molecular Function
    lysophospholipase activity GO:0004622 TAS
    lipid binding GO:0008289 IEA
    acylglycerol lipase activity GO:0047372 TAS
    protein homodimerization activity GO:0042803 IPI
Biological Process
    regulation of axon extension GO:0030516 IEA
    acylglycerol catabolic process GO:0046464 ISS
    acylglycerol acyl-chain remodeling GO:0036155 TAS
    regulation of inflammatory response GO:0050727 ISS
    small molecule metabolic process GO:0044281 TAS
    regulation of signal transduction GO:0009966 ISS
    long term synaptic depression GO:0060292 IEA
    arachidonic acid metabolic process GO:0019369 ISS
    fatty acid biosynthetic process GO:0006633 IEA
    inflammatory response GO:0006954 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
    lipid metabolic process GO:0006629 TAS
    regulation of endocannabinoid signaling pathway GO:2000124 ISS
    phospholipid metabolic process GO:0006644 TAS
    triglyceride catabolic process GO:0019433 TAS
    blood coagulation GO:0007596 TAS
    regulation of sensory perception of pain GO:0051930 ISS
    platelet activation GO:0030168 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 TAS
    varicosity GO:0043196 IEA
    extrinsic component of membrane GO:0019898 ISS
    synapse GO:0045202 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified MGLL in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MGLL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHGB  
Two-hybrid Homo sapiens
View the network image/svg+xml



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