Gene description for POFUT2
Gene name protein O-fucosyltransferase 2
Gene symbol POFUT2
Other names/aliases C21orf80
FUT13
Species Homo sapiens
 Database cross references - POFUT2
ExoCarta ExoCarta_23275
Entrez Gene 23275
HGNC 14683
MIM 610249
UniProt Q9Y2G5  
 POFUT2 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
 Gene ontology annotations for POFUT2
Molecular Function
    peptide-O-fucosyltransferase activity GO:0046922 IDA
Biological Process
    regulation of gene expression GO:0010468 IEA
    protein O-linked fucosylation GO:0036066 TAS
    fucose metabolic process GO:0006004 IEA
    regulation of secretion GO:0051046 IDA
    cellular protein metabolic process GO:0044267 TAS
    protein O-linked glycosylation GO:0006493 TAS
    post-translational protein modification GO:0043687 TAS
    regulation of epithelial to mesenchymal transition GO:0010717 IEA
    mesoderm formation GO:0001707 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified POFUT2 in exosomes
1
Experiment ID 76
ISEV standards
EM
EV Biophysical techniques
TSG101|GAPDH|HSP90
EV Cytosolic markers
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
 Protein-protein interactions for POFUT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which POFUT2 is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins TAS Reactome





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