Gene description for KCNMA1
Gene name potassium channel, calcium activated large conductance subfamily M alpha, member 1
Gene symbol KCNMA1
Other names/aliases BKTM
Species Homo sapiens
 Database cross references - KCNMA1
ExoCarta ExoCarta_3778
Entrez Gene 3778
HGNC 6284
MIM 600150
UniProt Q12791  
 KCNMA1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KCNMA1
Molecular Function
    actin binding GO:0003779 IDA
    protein binding GO:0005515 IPI
    voltage-gated potassium channel activity GO:0005249 IDA
    large conductance calcium-activated potassium channel activity GO:0060072 IMP
    metal ion binding GO:0046872 IEA
    calcium-activated potassium channel activity GO:0015269 IDA
Biological Process
    synaptic transmission GO:0007268 TAS
    response to carbon monoxide GO:0034465 IMP
    micturition GO:0060073 IDA
    response to hypoxia GO:0001666 IDA
    potassium ion transmembrane transport GO:0071805 IEA
    potassium ion transport GO:0006813 IDA
    negative regulation of cell volume GO:0045794 IDA
    regulation of ion transmembrane transport GO:0034765 IEA
    response to osmotic stress GO:0006970 IDA
    cellular potassium ion homeostasis GO:0030007 IDA
    smooth muscle contraction involved in micturition GO:0060083 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    regulation of membrane potential GO:0042391 IDA
    response to calcium ion GO:0051592 IDA
    blood coagulation GO:0007596 TAS
Subcellular Localization
    caveola GO:0005901 IDA
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IDA
    voltage-gated potassium channel complex GO:0008076 IDA
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified KCNMA1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNMA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNMB1  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which KCNMA1 is involved
Ca2+ activated K+ channels TAS Reactome
cGMP effects TAS Reactome

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