|
 Gene description for KCNMA1 |
| Gene name |
potassium channel, calcium activated large conductance subfamily M alpha, member 1 |
| Gene symbol |
KCNMA1 |
| Other names/aliases |
BKTM
KCa1.1
MaxiK
SAKCA
SLO
SLO-ALPHA
SLO1
bA205K10.1
mSLO1 |
| Species |
Homo sapiens |
| Database cross references - KCNMA1 |
| ExoCarta |
ExoCarta_3778 |
| Vesiclepedia |
VP_3778 |
| Entrez Gene |
3778 |
| HGNC |
6284 |
| MIM |
600150 |
| UniProt |
Q12791
|
| KCNMA1 identified in exosomes derived from the following tissue/cell type |
|
Hepatocellular carcinoma cells
|
26054723
|
|
Mesenchymal stem cells
|
36408942
|
| Gene ontology annotations for KCNMA1 |
|
|
| Experiment description of studies that identified KCNMA1 in exosomes |
| 1 |
| Experiment ID |
235 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
TSG101|Alix|HSC70|GAPDH
|
EV Enriched markers |
|
✔
HSP90B1
|
EV Negative markers |
|
✔
qNano
|
EV Particle analysis
|
|
| Identified molecule |
mRNA
|
| Identification method |
RNA Sequencing
|
| PubMed ID |
26054723
|
| Organism |
Homo sapiens |
| Experiment description |
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs |
| Authors |
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N |
| Journal name |
Carcinogenesis
|
| Publication year |
2015 |
| Sample |
Hepatocellular carcinoma cells |
| Sample name |
HKCI-8 |
| Isolation/purification methods |
Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient |
| Flotation density |
1.13-1.19 g/mL
|
| Molecules identified in the study |
Protein
RNA |
| Methods used in the study |
Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing |
|
|
| 2 |
| Experiment ID |
488 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
|
EV Enriched markers |
|
✔
CANX
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
Protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
36408942
|
| Organism |
Homo sapiens |
| Experiment description |
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells |
| Authors |
Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ. |
| Journal name |
Proteomics
|
| Publication year |
2023 |
| Sample |
Mesenchymal stem cells |
| Sample name |
UCMSC |
| Isolation/purification methods |
Differential centrifugation
Filtration
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectometry |
|
|
| Protein-protein interactions for KCNMA1 |
|
|
| Pathways in which KCNMA1 is involved |
|
|
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