Gene description for CLRN3
Gene name
clarin 3
Gene symbol
CLRN3
Other names/aliases
TMEM12 USH3AL1
Species
Homo sapiens
Database cross references - CLRN3
ExoCarta
ExoCarta_119467
Vesiclepedia
VP_119467
Entrez Gene
119467
HGNC
20795
UniProt
Q8NCR9
CLRN3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells
34887515
Urine
19056867
Gene ontology annotations for CLRN3
Experiment description of studies that identified CLRN3 in exosomes
1
Experiment ID
1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
34887515
Organism
Homo sapiens
Experiment description
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors
"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Colorectal cancer cells
Sample name
DiFi
Isolation/purification methods
Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation
Flotation density
-
Molecules identified in the study
Protein miRNA
Methods used in the study
Western blotting Mass spectrometry RNA sequencing
2
Experiment ID
63
MISEV standards
✘
Biophysical techniques
✔
AQP2
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
19056867
Organism
Homo sapiens
Experiment description
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors
"Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name
JASN
Publication year
2009
Sample
Urine
Sample name
Urine - Normal
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [LTQ] Western blotting
Protein-protein interactions for CLRN3
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
TXNDC9
10190
Affinity Capture-MS
Homo sapiens
2
NME2P1
283458
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
3
ZDHHC17
23390
Two-hybrid
Homo sapiens
4
HCCS
3052
Affinity Capture-MS
Homo sapiens
5
PPAN
56342
Cross-Linking-MS (XL-MS)
Homo sapiens
6
CCDC43
124808
Affinity Capture-MS
Homo sapiens
7
ERICH6
Cross-Linking-MS (XL-MS)
Homo sapiens
8
GOLGA6C
Cross-Linking-MS (XL-MS)
Homo sapiens
9
GOLGA6A
Cross-Linking-MS (XL-MS)
Homo sapiens
10
PPP4R4
57718
Cross-Linking-MS (XL-MS)
Homo sapiens
11
GOLGA6D
Cross-Linking-MS (XL-MS)
Homo sapiens
12
GOLGA6B
Cross-Linking-MS (XL-MS)
Homo sapiens
View the network
image/svg+xml
Pathways in which CLRN3 is involved
No pathways found