Gene description for CLRN3
Gene name clarin 3
Gene symbol CLRN3
Other names/aliases TMEM12
USH3AL1
Species Homo sapiens
 Database cross references - CLRN3
ExoCarta ExoCarta_119467
Vesiclepedia VP_119467
Entrez Gene 119467
HGNC 20795
UniProt Q8NCR9  
 CLRN3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Urine 19056867    
 Gene ontology annotations for CLRN3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    sensory perception of sound GO:0007605 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CLRN3 in exosomes
1
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CLRN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TXNDC9 10190
Affinity Capture-MS Homo sapiens
2 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZDHHC17 23390
Two-hybrid Homo sapiens
4 HCCS 3052
Affinity Capture-MS Homo sapiens
5 PPAN 56342
Cross-Linking-MS (XL-MS) Homo sapiens
6 CCDC43 124808
Affinity Capture-MS Homo sapiens
7 ERICH6  
Cross-Linking-MS (XL-MS) Homo sapiens
8 GOLGA6C  
Cross-Linking-MS (XL-MS) Homo sapiens
9 GOLGA6A  
Cross-Linking-MS (XL-MS) Homo sapiens
10 PPP4R4 57718
Cross-Linking-MS (XL-MS) Homo sapiens
11 GOLGA6D  
Cross-Linking-MS (XL-MS) Homo sapiens
12 GOLGA6B  
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which CLRN3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here