Gene description for TMCC1
Gene name transmembrane and coiled-coil domain family 1
Gene symbol TMCC1
Other names/aliases -
Species Homo sapiens
 Database cross references - TMCC1
ExoCarta ExoCarta_23023
Vesiclepedia VP_23023
Entrez Gene 23023
HGNC 29116
MIM 616242
UniProt O94876  
 TMCC1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TMCC1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    endoplasmic reticulum organization GO:0007029 IMP
    endosomal transport GO:0016197 IBA
    endosomal transport GO:0016197 IDA
    membrane fission GO:0090148 IBA
    membrane fission GO:0090148 IDA
    endosome membrane tubulation GO:0097750 IBA
    endosome membrane tubulation GO:0097750 IDA
    endosome fission GO:0140285 IBA
    endosome fission GO:0140285 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    rough endoplasmic reticulum GO:0005791 IMP
    cytosol GO:0005829 IMP
    endomembrane system GO:0012505 IBA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IDA
 Experiment description of studies that identified TMCC1 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TMCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 TEX28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MAPRE1 22919
Affinity Capture-MS Homo sapiens
4 ZDHHC17 23390
Two-hybrid Homo sapiens
5 DNAJC1 64215
Proximity Label-MS Homo sapiens
6 APEX1 328
Affinity Capture-RNA Homo sapiens
7 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
8 PTPN1 5770
Proximity Label-MS Homo sapiens
9 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which TMCC1 is involved
No pathways found





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