Gene description for ACSS2
Gene name acyl-CoA synthetase short-chain family member 2
Gene symbol ACSS2
Other names/aliases ACAS2
ACECS
ACS
ACSA
dJ1161H23.1
Species Homo sapiens
 Database cross references - ACSS2
ExoCarta ExoCarta_55902
Entrez Gene 55902
HGNC 15814
MIM 605832
UniProt Q9NR19  
 ACSS2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ACSS2
Molecular Function
    acetate-CoA ligase activity GO:0003987 IDA
    ATP binding GO:0005524 IEA
    AMP binding GO:0016208 IC
Biological Process
    propionate biosynthetic process GO:0019542 IEA
    xenobiotic metabolic process GO:0006805 TAS
    ethanol oxidation GO:0006069 TAS
    lipid biosynthetic process GO:0008610 IMP
    small molecule metabolic process GO:0044281 TAS
    acetate biosynthetic process GO:0019413 IEA
    acetyl-CoA biosynthetic process from acetate GO:0019427 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ACSS2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACSS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACSS2 is involved
PathwayEvidenceSource
Ethanol oxidation TAS Reactome





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