Gene description for CYP2D6
Gene name cytochrome P450, family 2, subfamily D, polypeptide 6
Gene symbol CYP2D6
Other names/aliases CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
Species Homo sapiens
 Database cross references - CYP2D6
ExoCarta ExoCarta_1565
Entrez Gene 1565
HGNC 2625
MIM 124030
UniProt P10635  
 CYP2D6 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CYP2D6
Molecular Function
    oxygen binding GO:0019825 IBA
    iron ion binding GO:0005506 IEA
    oxidoreductase activity GO:0016491 IDA
    steroid hydroxylase activity GO:0008395 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    heme binding GO:0020037 IDA
    arachidonic acid epoxygenase activity GO:0008392 IBA
    aromatase activity GO:0070330 IEA
    monooxygenase activity GO:0004497 IDA
    drug binding GO:0008144 IDA
Biological Process
    xenobiotic metabolic process GO:0006805 TAS
    coumarin metabolic process GO:0009804 IDA
    drug catabolic process GO:0042737 IDA
    isoquinoline alkaloid metabolic process GO:0033076 IDA
    monoterpenoid metabolic process GO:0016098 IDA
    negative regulation of cellular organofluorine metabolic process GO:0090350 IDA
    alkaloid metabolic process GO:0009820 IDA
    small molecule metabolic process GO:0044281 TAS
    oxidation-reduction process GO:0055114 IDA
    exogenous drug catabolic process GO:0042738 IBA
    arachidonic acid metabolic process GO:0019369 IBA
    oxidative demethylation GO:0070989 IDA
    alkaloid catabolic process GO:0009822 IDA
    heterocycle metabolic process GO:0046483 IDA
    drug metabolic process GO:0017144 IMP
    steroid metabolic process GO:0008202 IMP
    negative regulation of binding GO:0051100 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum GO:0005783 TAS
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified CYP2D6 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CYP2D6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CYP2D6 is involved
PathwayEvidenceSource
CYP2E1 reactions TAS Reactome
Fatty acids TAS Reactome
Miscellaneous substrates TAS Reactome
Xenobiotics TAS Reactome





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