Gene description for H3F3A
Gene name H3 histone, family 3A
Gene symbol H3F3A
Other names/aliases -
Species Bos taurus
 Database cross references - H3F3A
ExoCarta ExoCarta_326601
Vesiclepedia VP_326601
Entrez Gene 326601
UniProt Q5E9F8  
 H3F3A identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for H3F3A
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Subcellular Localization
    nucleosome GO:0000786 IEA
 Experiment description of studies that identified H3F3A in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for H3F3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mgea5  
Biochemical Activity Mus musculus
2 CBX3 11335
Reconstituted Complex Homo sapiens
3 Cbx5  
Affinity Capture-Western Mus musculus
4 CARM1 10498
Biochemical Activity Homo sapiens
5 SMARCA2 6595
Reconstituted Complex Homo sapiens
6 Uhrf1  
Far Western Mus musculus
7 Ep300  
Biochemical Activity Mus musculus
8 KDM4A  
Biochemical Activity Homo sapiens
9 MORF4L1  
Affinity Capture-Western Homo sapiens
10 CBX5 23468
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which H3F3A is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 IEA Reactome
Assembly of the ORC complex at the origin of replication IEA Reactome
Assembly of the pre-replicative complex IEA Reactome
B-WICH complex positively regulates rRNA expression IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromosome Maintenance IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
DNA Replication IEA Reactome
DNA Replication Pre-Initiation IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA IEA Reactome
Generic Transcription Pathway IEA Reactome
Hemostasis IEA Reactome
Inhibition of DNA recombination at telomere IEA Reactome
M Phase IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Oxidative Stress Induced Senescence IEA Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RNA Polymerase I Promoter Clearance IEA Reactome
RNA Polymerase I Promoter Escape IEA Reactome
RNA Polymerase I Promoter Opening IEA Reactome
RNA Polymerase I Transcription IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) IEA Reactome
Signal Transduction IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
SIRT1 negatively regulates rRNA expression IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Telomere Maintenance IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs IEA Reactome





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