Gene description for ABR
Gene name active BCR-related
Gene symbol ABR
Other names/aliases MDB
Species Homo sapiens
 Database cross references - ABR
ExoCarta ExoCarta_29
Entrez Gene 29
HGNC 81
MIM 600365
UniProt Q12979  
 ABR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ABR
Molecular Function
    GTPase activator activity GO:0005096 IEA
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
Biological Process
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    actin cytoskeleton organization GO:0030036 IEA
    neuromuscular process controlling balance GO:0050885 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    positive regulation of apoptotic process GO:0043065 TAS
    brain development GO:0007420 IEA
    apoptotic signaling pathway GO:0097190 TAS
    negative regulation of inflammatory response GO:0050728 IEA
    inner ear morphogenesis GO:0042472 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of phagocytosis GO:0050766 IEA
    positive regulation of GTPase activity GO:0043547 TAS
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of cell migration GO:0030336 IEA
    negative regulation of neutrophil degranulation GO:0043314 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ABR in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ABR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ABR is involved
PathwayEvidenceSource
G alpha (12/13) signalling events TAS Reactome
NRAGE signals death through JNK TAS Reactome
Rho GTPase cycle TAS Reactome





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