Gene description for FLRT3
Gene name fibronectin leucine rich transmembrane protein 3
Gene symbol FLRT3
Other names/aliases HH21
Species Homo sapiens
 Database cross references - FLRT3
ExoCarta ExoCarta_23767
Vesiclepedia VP_23767
Entrez Gene 23767
HGNC 3762
MIM 604808
UniProt Q9NZU0  
 FLRT3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FLRT3
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IEA
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 NAS
    protein homodimerization activity GO:0042803 IDA
    chemorepellent activity GO:0045499 IEA
Biological Process
    proepicardium cell migration involved in pericardium morphogenesis GO:0003345 ISS
    axon guidance GO:0007411 IEA
    synapse assembly GO:0007416 ISS
    heart development GO:0007507 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 ISS
    neuron projection development GO:0031175 ISS
    embryonic morphogenesis GO:0048598 ISS
    response to axon injury GO:0048678 ISS
    negative chemotaxis GO:0050919 IEA
    positive regulation of synapse assembly GO:0051965 IEA
    head development GO:0060322 ISS
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IDA
    synaptic membrane adhesion GO:0099560 IEA
    neuron projection extension GO:1990138 IMP
    neuron projection extension GO:1990138 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    focal adhesion GO:0005925 IEA
    cell junction GO:0030054 IDA
    extracellular matrix GO:0031012 NAS
    growth cone membrane GO:0032584 IEA
    axon terminus GO:0043679 ISS
    axonal growth cone GO:0044295 ISS
    postsynaptic membrane GO:0045211 IEA
    synaptic membrane GO:0097060 ISS
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified FLRT3 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FLRT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MCAM 4162
Proximity Label-MS Homo sapiens
3 KRAS 3845
Proximity Label-MS Homo sapiens
4 EFNA1  
Affinity Capture-MS Homo sapiens
5 GJA1 2697
Proximity Label-MS Homo sapiens
6 CAV1 857
Proximity Label-MS Homo sapiens
7 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ARF6 382
Proximity Label-MS Homo sapiens
9 C11orf52 91894
Proximity Label-MS Homo sapiens
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