Gene description for OTUD3
Gene name OTU deubiquitinase 3
Gene symbol OTUD3
Other names/aliases DUBA4
Species Homo sapiens
 Database cross references - OTUD3
ExoCarta ExoCarta_23252
Entrez Gene 23252
HGNC 29038
MIM 611758
UniProt Q5T2D3  
 OTUD3 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for OTUD3
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    protein K11-linked deubiquitination GO:0035871 IDA
    protein K6-linked deubiquitination GO:0044313 IDA
 Experiment description of studies that identified OTUD3 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for OTUD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OTUD3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here