Gene description for DGKA
Gene name diacylglycerol kinase, alpha 80kDa
Gene symbol DGKA
Other names/aliases DAGK
DAGK1
DGK-alpha
Species Homo sapiens
 Database cross references - DGKA
ExoCarta ExoCarta_1606
Entrez Gene 1606
HGNC 2849
MIM 125855
UniProt P23743  
 DGKA identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DGKA
Molecular Function
    ATP binding GO:0005524 IEA
    diacylglycerol kinase activity GO:0004143 IEA
    phospholipid binding GO:0005543 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    blood coagulation GO:0007596 TAS
    platelet activation GO:0030168 TAS
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 IEA
    intracellular signal transduction GO:0035556 IEA
    phosphorylation GO:0016310 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified DGKA in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DGKA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL2  
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which DGKA is involved
PathwayEvidenceSource
Effects of PIP2 hydrolysis TAS Reactome





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