Gene description for ALKBH7
Gene name alkB, alkylation repair homolog 7 (E. coli)
Gene symbol ALKBH7
Other names/aliases ABH7
SPATA11
UNQ6002
Species Homo sapiens
 Database cross references - ALKBH7
ExoCarta ExoCarta_84266
Vesiclepedia VP_84266
Entrez Gene 84266
HGNC 21306
MIM 613305
UniProt Q9BT30  
 ALKBH7 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ALKBH7
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    dioxygenase activity GO:0051213 IEA
Biological Process
    fatty acid metabolic process GO:0006631 IBA
    fatty acid metabolic process GO:0006631 ISS
    DNA damage response GO:0006974 IDA
    regulation of lipid storage GO:0010883 ISS
    regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified ALKBH7 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ALKBH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 KIAA1217 56243
Two-hybrid Homo sapiens
3 C20orf85  
Two-hybrid Homo sapiens
4 C19orf38  
Affinity Capture-MS Homo sapiens
5 CENPN  
Two-hybrid Homo sapiens
6 B9D2 80776
Two-hybrid Homo sapiens
7 LOXL2 4017
Affinity Capture-MS Homo sapiens
8 HRASLS  
Affinity Capture-MS Homo sapiens
9 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTA2 9219
Affinity Capture-MS Homo sapiens
11 ESR1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ALKBH7 is involved
No pathways found





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