Gene description for CREG1
Gene name cellular repressor of E1A-stimulated genes 1
Gene symbol CREG1
Other names/aliases CREG
Species Homo sapiens
 Database cross references - CREG1
ExoCarta ExoCarta_8804
Vesiclepedia VP_8804
Entrez Gene 8804
HGNC 2351
UniProt O75629  
 CREG1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CREG1
Molecular Function
    transcription corepressor activity GO:0003714 TAS
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    endocytosis GO:0006897 IEA
    autophagy GO:0006914 IEA
    lysosomal lumen acidification GO:0007042 IEA
    negative regulation of DNA-templated transcription GO:0045892 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    transcription regulator complex GO:0005667 IEA
    endosome GO:0005768 IEA
    azurophil granule lumen GO:0035578 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CREG1 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CREG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBL1  
Reconstituted Complex Homo sapiens
2 MRM1  
Affinity Capture-MS Homo sapiens
3 PMPCB 9512
Co-fractionation Homo sapiens
4 ATG9A 79065
Proximity Label-MS Homo sapiens
5 SH2D3A  
Affinity Capture-MS Homo sapiens
6 E2F4  
Affinity Capture-MS Homo sapiens
7 DLD 1738
Co-fractionation Homo sapiens
8 PCP4  
Affinity Capture-MS Homo sapiens
9 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
10 PTDSS1 9791
Affinity Capture-MS Homo sapiens
11 FBXO6 26270
Affinity Capture-MS Homo sapiens
12 ST7  
Affinity Capture-MS Homo sapiens
13 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TBP  
Reconstituted Complex Homo sapiens
15 GRHPR 9380
Co-fractionation Homo sapiens
16 RB1 5925
Reconstituted Complex Homo sapiens
17 FBXO2 26232
Affinity Capture-MS Homo sapiens
18 PMPCA 23203
Co-fractionation Homo sapiens
19 AIRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TPI1 7167
Co-fractionation Homo sapiens
21 IGF2R 3482
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
22 LHPP 64077
Affinity Capture-MS Homo sapiens
23 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CREG1 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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