Gene description for CREG1
Gene name cellular repressor of E1A-stimulated genes 1
Gene symbol CREG1
Other names/aliases CREG
Species Homo sapiens
 Database cross references - CREG1
ExoCarta ExoCarta_8804
Vesiclepedia VP_8804
Entrez Gene 8804
HGNC 2351
UniProt O75629  
 CREG1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CREG1
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    transcription factor binding GO:0008134 IEA
    transcription corepressor activity GO:0003714 TAS
    FMN binding GO:0010181 IEA
Biological Process
    cell proliferation GO:0008283 TAS
    negative regulation of nucleic acid-templated transcription GO:1903507 TAS
    oxidation-reduction process GO:0055114 IEA
    multicellular organismal development GO:0007275 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    regulation of growth GO:0040008 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    transcription factor complex GO:0005667 IEA
 Experiment description of studies that identified CREG1 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CREG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Reconstituted Complex Homo sapiens
2 RBL1  
Reconstituted Complex Homo sapiens
3 TBP  
Reconstituted Complex Homo sapiens
4 IGF2R 3482
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CREG1 is involved
No pathways found





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