Gene description for PLXND1
Gene name plexin D1
Gene symbol PLXND1
Other names/aliases PLEXD1
Species Homo sapiens
 Database cross references - PLXND1
ExoCarta ExoCarta_23129
Entrez Gene 23129
HGNC 9107
MIM 604282
UniProt Q9Y4D7  
 PLXND1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for PLXND1
Molecular Function
    protein binding GO:0005515 IPI
    semaphorin receptor activity GO:0017154 ISS
    protein domain specific binding GO:0019904 IPI
Biological Process
    patterning of blood vessels GO:0001569 IEA
    regulation of angiogenesis GO:0045765 ISS
    semaphorin-plexin signaling pathway GO:0071526 ISS
    outflow tract morphogenesis GO:0003151 IEA
    regulation of cell migration GO:0030334 ISS
    synapse assembly GO:0007416 ISS
    endothelial cell migration GO:0043542 ISS
    dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 IEA
    axon guidance GO:0007411 TAS
    angiogenesis GO:0001525 ISS
    positive regulation of protein binding GO:0032092 IEA
Subcellular Localization
    lamellipodium GO:0030027 IDA
    integral component of plasma membrane GO:0005887 ISS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified PLXND1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLXND1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PLXND1 is involved
PathwayEvidenceSource
Other semaphorin interactions TAS Reactome





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