Gene description for KLHL41
Gene name kelch-like family member 41
Gene symbol KLHL41
Other names/aliases KBTBD10
Krp1
SARCOSIN
Species Homo sapiens
 Database cross references - KLHL41
ExoCarta ExoCarta_10324
Vesiclepedia VP_10324
Entrez Gene 10324
HGNC 16905
MIM 607701
UniProt O60662  
 KLHL41 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KLHL41
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IBA
Biological Process
    striated muscle contraction GO:0006941 TAS
    protein ubiquitination GO:0016567 IDA
    myofibril assembly GO:0030239 ISS
    pseudopodium assembly GO:0031269 IEA
    skeletal muscle cell differentiation GO:0035914 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    regulation of myoblast differentiation GO:0045661 IBA
    regulation of myoblast differentiation GO:0045661 ISS
    regulation of myoblast proliferation GO:2000291 IBA
    regulation of myoblast proliferation GO:2000291 ISS
    regulation of skeletal muscle cell differentiation GO:2001014 IBA
Subcellular Localization
    ruffle GO:0001726 IEA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 ISS
    plasma membrane GO:0005886 IDA
    pseudopodium GO:0031143 IEA
    M band GO:0031430 IBA
    M band GO:0031430 ISS
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
    sarcoplasmic reticulum membrane GO:0033017 IBA
    sarcoplasmic reticulum membrane GO:0033017 IDA
 Experiment description of studies that identified KLHL41 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KLHL41
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 KIAA1324 57535
Affinity Capture-MS Homo sapiens
3 NRAP  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
4 C4orf45  
Two-hybrid Homo sapiens
5 RBM4 5936
Two-hybrid Homo sapiens
6 CUL3 8452
Affinity Capture-Western Homo sapiens
7 NEB 4703
FRET Homo sapiens
Two-hybrid Homo sapiens
8 RBX1 9978
Affinity Capture-Western Homo sapiens
9 KLHL41 10324
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
10 FOXF2  
Affinity Capture-MS Homo sapiens
11 RCHY1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 IFRD1 3475
Two-hybrid Homo sapiens
13 SLC2A4  
Affinity Capture-MS Homo sapiens
14 KLHL40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 BEX4  
Affinity Capture-MS Homo sapiens
16 UTP11L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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