Gene description for TNFRSF12A
Gene name tumor necrosis factor receptor superfamily, member 12A
Gene symbol TNFRSF12A
Other names/aliases CD266
FN14
TWEAKR
Species Homo sapiens
 Database cross references - TNFRSF12A
ExoCarta ExoCarta_51330
Entrez Gene 51330
HGNC 18152
MIM 605914
UniProt Q9NP84  
 TNFRSF12A identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TNFRSF12A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    substrate-dependent cell migration, cell attachment to substrate GO:0006931 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    regulation of wound healing GO:0061041 IDA
    regulation of angiogenesis GO:0045765 IEA
    angiogenesis GO:0001525 IEA
    positive regulation of axon extension GO:0045773 IEA
Subcellular Localization
    cell surface GO:0009986 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    ruffle GO:0001726 IEA
 Experiment description of studies that identified TNFRSF12A in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TNFRSF12A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 TRAF1 7185
Reconstituted Complex Homo sapiens
3 TNFSF12 8742
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNFRSF12A is involved
No pathways found





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