Gene description for APOBEC3A
Gene name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
Gene symbol APOBEC3A
Other names/aliases A3A
ARP3
PHRBN
bK150C2.1
Species Homo sapiens
 Database cross references - APOBEC3A
ExoCarta ExoCarta_200315
Vesiclepedia VP_200315
Entrez Gene 200315
HGNC 17343
MIM 607109
UniProt P31941  
 APOBEC3A identified in sEVs derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for APOBEC3A
Molecular Function
    RNA binding GO:0003723 IBA
    cytidine deaminase activity GO:0004126 IBA
    cytidine deaminase activity GO:0004126 IDA
    cytidine deaminase activity GO:0004126 IMP
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    transposable element silencing GO:0010526 IDA
    cytidine to uridine editing GO:0016554 IBA
    positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 IDA
    clearance of foreign intracellular DNA GO:0044355 IDA
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IDA
    negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 IBA
    defense response to virus GO:0051607 IBA
    defense response to virus GO:0051607 IDA
    DNA cytosine deamination GO:0070383 IBA
Subcellular Localization
    P-body GO:0000932 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified APOBEC3A in sEVs
1
Experiment ID 189
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
EM
Biophysical techniques
HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOBEC3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DDX19B 11269
Affinity Capture-MS Homo sapiens
2 STAMBP 10617
Two-hybrid Homo sapiens
3 CUL2 8453
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 CDK15  
Affinity Capture-MS Homo sapiens
5 SIK1  
Affinity Capture-MS Homo sapiens
6 H2AFB1  
Affinity Capture-MS Homo sapiens
7 AGPAT1 10554
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which APOBEC3A is involved
PathwayEvidenceSource
Formation of the Editosome TAS Reactome
Metabolism of RNA TAS Reactome
mRNA Editing TAS Reactome
mRNA Editing: C to U Conversion TAS Reactome





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