Gene description for RGS6
Gene name regulator of G-protein signaling 6
Gene symbol RGS6
Other names/aliases GAP
Species Homo sapiens
 Database cross references - RGS6
ExoCarta ExoCarta_9628
Entrez Gene 9628
HGNC 10002
MIM 603894
UniProt P49758  
 RGS6 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for RGS6
Molecular Function
    signal transducer activity GO:0004871 IEA
    protein domain specific binding GO:0019904 IEA
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    intracellular signal transduction GO:0035556 IEA
    positive regulation of neuron differentiation GO:0045666 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
    heterotrimeric G-protein complex GO:0005834 IEA
 Experiment description of studies that identified RGS6 in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STMN2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 DNMT1 1786
Reconstituted Complex Homo sapiens
3 DMAP1 55929
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RGS6 is involved
PathwayEvidenceSource
G alpha (i) signalling events TAS Reactome





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