Gene description for DBF4B
Gene name DBF4 zinc finger B
Gene symbol DBF4B
Other names/aliases ASKL1
CHIFB
DRF1
ZDBF1B
Species Homo sapiens
 Database cross references - DBF4B
ExoCarta ExoCarta_80174
Vesiclepedia VP_80174
Entrez Gene 80174
HGNC 17883
MIM 611661
UniProt Q8NFT6  
 DBF4B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for DBF4B
Molecular Function
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    protein kinase binding GO:0019901 IPI
    protein kinase activator activity GO:0030295 IDA
    protein serine/threonine kinase activator activity GO:0043539 IBA
Biological Process
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of nuclear cell cycle DNA replication GO:0010571 IBA
    positive regulation of nuclear cell cycle DNA replication GO:0010571 IMP
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IMP
    regulation of cell cycle phase transition GO:1901987 IBA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    Dbf4-dependent protein kinase complex GO:0031431 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified DBF4B in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for DBF4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP1S 55201
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SRPK2 6733
Biochemical Activity Homo sapiens
3 OXSM  
Affinity Capture-MS Homo sapiens
4 MDFI  
Two-hybrid Homo sapiens
5 PTEN 5728
Affinity Capture-MS Homo sapiens
6 MAP1B 4131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 APEX1 328
Affinity Capture-RNA Homo sapiens
8 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LMO2  
Two-hybrid Homo sapiens
10 KRTAP4-12  
Two-hybrid Homo sapiens
11 KDM1A 23028
Two-hybrid Homo sapiens
12 GEM  
Two-hybrid Homo sapiens
13 HEXIM2  
Two-hybrid Homo sapiens
14 LRRK2 120892
Reconstituted Complex Homo sapiens
15 CYSRT1 375791
Two-hybrid Homo sapiens
16 FUS 2521
Affinity Capture-MS Homo sapiens
17 TRIM27  
Two-hybrid Homo sapiens
18 ZNF655  
Two-hybrid Homo sapiens
19 CCDC101  
Two-hybrid Homo sapiens
20 SUV39H1  
Two-hybrid Homo sapiens
21 SCRN2 90507
Affinity Capture-MS Homo sapiens
22 CDC7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX39B 7919
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DBF4B is involved
No pathways found





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