Gene description for ANG
Gene name angiogenin, ribonuclease, RNase A family, 5
Gene symbol ANG
Other names/aliases ALS9
HEL168
RAA1
RNASE4
RNASE5
Species Homo sapiens
 Database cross references - ANG
ExoCarta ExoCarta_283
Vesiclepedia VP_283
Entrez Gene 283
HGNC 483
MIM 105850
UniProt P03950  
 ANG identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ANG
Molecular Function
    endonuclease activity GO:0004519 TAS
    receptor binding GO:0005102 IDA
    protein homodimerization activity GO:0042803 IDA
    rRNA binding GO:0019843 TAS
    copper ion binding GO:0005507 IDA
    peptide binding GO:0042277 IDA
    ribonuclease activity GO:0004540 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IC
    heparin binding GO:0008201 IDA
    actin binding GO:0003779 IDA
Biological Process
    activation of protein kinase B activity GO:0032148 IMP
    cell migration GO:0016477 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IDA
    rRNA transcription GO:0009303 IMP
    activation of phospholipase C activity GO:0007202 IMP
    oocyte maturation GO:0001556 NAS
    placenta development GO:0001890 NAS
    positive regulation of protein secretion GO:0050714 ISS
    nucleic acid phosphodiester bond hydrolysis GO:0090305 TAS
    RNA phosphodiester bond hydrolysis GO:0090501 IDA
    positive regulation of phosphorylation GO:0042327 IDA
    angiogenesis GO:0001525 TAS
    ovarian follicle development GO:0001541 NAS
    homeostatic process GO:0042592 NAS
    response to hypoxia GO:0001666 NAS
    response to hormone GO:0009725 IDA
    negative regulation of translation GO:0017148 IEA
    negative regulation of smooth muscle cell proliferation GO:0048662 IDA
    cell communication GO:0007154 NAS
    diacylglycerol biosynthetic process GO:0006651 IDA
    activation of phospholipase A2 activity GO:0032431 IMP
    actin filament polymerization GO:0030041 ISS
Subcellular Localization
    growth cone GO:0030426 ISS
    extracellular exosome GO:0070062 IDA
    basal lamina GO:0005605 IDA
    angiogenin-PRI complex GO:0032311 IPI
    neuronal cell body GO:0043025 ISS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 ISS
 Experiment description of studies that identified ANG in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ANG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTC1 70
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 TDGF1  
Two-hybrid Homo sapiens
3 RNH1 6050
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 ATP6AP1  
Two-hybrid Homo sapiens
5 PTEN 5728
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ANG is involved
No pathways found





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