Gene description for EME2
Gene name essential meiotic structure-specific endonuclease subunit 2
Gene symbol EME2
Other names/aliases SLX2B
gs125
Species Homo sapiens
 Database cross references - EME2
ExoCarta ExoCarta_197342
Vesiclepedia VP_197342
Entrez Gene 197342
HGNC 27289
MIM 610886
UniProt A4GXA9  
 EME2 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for EME2
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    crossover junction DNA endonuclease activity GO:0008821 IBA
Biological Process
    resolution of meiotic recombination intermediates GO:0000712 IBA
    double-strand break repair GO:0006302 IBA
    double-strand break repair GO:0006302 IDA
    replication fork processing GO:0031297 IBA
    replication fork processing GO:0031297 IDA
    mitotic intra-S DNA damage checkpoint signaling GO:0031573 IBA
Subcellular Localization
    nuclear replication fork GO:0043596 NAS
    Holliday junction resolvase complex GO:0048476 IBA
    endodeoxyribonuclease complex GO:1905347 IPI
 Experiment description of studies that identified EME2 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EME2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEOX2  
Two-hybrid Homo sapiens
2 MUS81  
Reconstituted Complex Homo sapiens
3 C19orf40  
Reconstituted Complex Homo sapiens
4 FANCM 57697
Reconstituted Complex Homo sapiens
5 PTEN 5728
Synthetic Growth Defect Homo sapiens
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