Gene description for RAD54L
Gene name RAD54-like (S. cerevisiae)
Gene symbol RAD54L
Other names/aliases HR54
RAD54A
hHR54
hRAD54
Species Homo sapiens
 Database cross references - RAD54L
ExoCarta ExoCarta_8438
Entrez Gene 8438
HGNC 9826
MIM 603615
UniProt Q92698  
 RAD54L identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RAD54L
Molecular Function
    DNA binding GO:0003677 IEA
    annealing helicase activity GO:0036310 IDA
    protein binding GO:0005515 IPI
    helicase activity GO:0004386 IEA
    ATP binding GO:0005524 IEA
Biological Process
    chromosome organization GO:0051276 IEA
    DNA recombination GO:0006310 TAS
    meiotic nuclear division GO:0007126 TAS
    DNA strand renaturation GO:0000733 IDA
    DNA repair GO:0006281 TAS
    response to drug GO:0042493 IEA
    double-strand break repair via homologous recombination GO:0000724 IEA
    response to ionizing radiation GO:0010212 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified RAD54L in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RAD54L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RAD54L is involved
No pathways found





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