Gene description for TTBK2
Gene name tau tubulin kinase 2
Gene symbol TTBK2
Other names/aliases SCA11
TTBK
Species Homo sapiens
 Database cross references - TTBK2
ExoCarta ExoCarta_146057
Entrez Gene 146057
HGNC 19141
MIM 611695
UniProt Q6IQ55  
 TTBK2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TTBK2
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 IDA
Biological Process
    peptidyl-serine phosphorylation GO:0018105 IDA
    organelle organization GO:0006996 TAS
    regulation of cell shape GO:0008360 IBA
    smoothened signaling pathway GO:0007224 ISS
    cilium assembly GO:0042384 ISS
Subcellular Localization
    centriole GO:0005814 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    ciliary transition zone GO:0035869 ISS
    cytosol GO:0005829 TAS
    ciliary basal body GO:0036064 ISS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified TTBK2 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TTBK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TTBK1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TTBK2 is involved
PathwayEvidenceSource
Anchoring of the basal body to the plasma membrane TAS Reactome





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