Gene description for SCN10A
Gene name sodium channel, voltage gated, type X alpha subunit
Gene symbol SCN10A
Other names/aliases FEPS2
Nav1.8
PN3
SNS
hPN3
Species Homo sapiens
 Database cross references - SCN10A
ExoCarta ExoCarta_6336
Entrez Gene 6336
HGNC 10582
MIM 604427
UniProt Q9Y5Y9  
 SCN10A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SCN10A
Molecular Function
    voltage-gated sodium channel activity GO:0005248 IDA
    ion channel binding GO:0044325 IPI
Biological Process
    sensory perception GO:0007600 TAS
    bundle of His cell action potential GO:0086043 IMP
    neuronal action potential GO:0019228 IBA
    sensory perception of pain GO:0019233 IEA
    regulation of cardiac muscle contraction GO:0055117 IMP
    membrane depolarization during action potential GO:0086010 IBA
    AV node cell action potential GO:0086016 IMP
    regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 IMP
    sodium ion transmembrane transport GO:0035725 IDA
    regulation of heart rate GO:0002027 IMP
    regulation of ion transmembrane transport GO:0034765 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    C-fiber GO:0044299 IEA
    voltage-gated sodium channel complex GO:0001518 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SCN10A in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SCN10A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SCN10A is involved
PathwayEvidenceSource
Interaction between L1 and Ankyrins TAS Reactome





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