Gene description for ABCA7
Gene name	ATP-binding cassette, sub-family A (ABC1), member 7
Gene symbol	ABCA7
Other names/aliases	ABCA-SSN ABCX
Species	Homo sapiens
Database cross references - ABCA7
ExoCarta	ExoCarta_10347
Vesiclepedia	VP_10347
Entrez Gene	10347
HGNC	37
MIM	605414
UniProt	Q8IZY2
ABCA7 identified in sEVs derived from the following tissue/cell type
Plasma	19028452

Gene ontology annotations for ABCA7

Molecular Function     ATP binding GO:0005524 IEA     phospholipid transporter activity GO:0005548 IGI     ATP hydrolysis activity GO:0016887 IEA     apolipoprotein A-I receptor activity GO:0034188 IBA     apolipoprotein A-I receptor activity GO:0034188 IDA     ATPase-coupled transmembrane transporter activity GO:0042626 IBA     phosphatidylcholine floppase activity GO:0090554 IBA     phosphatidylcholine floppase activity GO:0090554 IDA     phosphatidylserine floppase activity GO:0090556 IBA     phosphatidylserine floppase activity GO:0090556 IDA     floppase activity GO:0140328 IDA     ABC-type transporter activity GO:0140359 IEA Biological Process     phagocytosis GO:0006909 IEA     memory GO:0007613 ISS     visual learning GO:0008542 ISS     positive regulation of cholesterol efflux GO:0010875 ISS     peptide cross-linking GO:0018149 ISS     regulation of lipid metabolic process GO:0019216 ISS     cholesterol efflux GO:0033344 IBA     cholesterol efflux GO:0033344 IDA     phospholipid efflux GO:0033700 IBA     phospholipid efflux GO:0033700 IDA     phospholipid efflux GO:0033700 IGI     amyloid-beta formation GO:0034205 IMP     high-density lipoprotein particle assembly GO:0034380 IDA     protein localization to nucleus GO:0034504 ISS     apolipoprotein A-I-mediated signaling pathway GO:0038027 IDA     negative regulation of amyloid precursor protein biosynthetic process GO:0042985 ISS     negative regulation of MAPK cascade GO:0043409 ISS     plasma membrane raft organization GO:0044857 ISS     phospholipid translocation GO:0045332 IDA     negative regulation of endocytosis GO:0045806 ISS     positive regulation of phagocytosis GO:0050766 ISS     transmembrane transport GO:0055085 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     amyloid-beta clearance by cellular catabolic process GO:0150094 ISS     positive regulation of amyloid-beta clearance GO:1900223 ISS     positive regulation of engulfment of apoptotic cell GO:1901076 ISS     negative regulation of amyloid-beta formation GO:1902430 ISS     regulation of amyloid precursor protein catabolic process GO:1902991 IMP     positive regulation of phospholipid efflux GO:1902995 ISS     negative regulation of PERK-mediated unfolded protein response GO:1903898 ISS     positive regulation of protein localization to cell surface GO:2000010 ISS Subcellular Localization     Golgi membrane GO:0000139 IEA     phagocytic cup GO:0001891 ISS     endoplasmic reticulum GO:0005783 IEA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 ISS     cell junction GO:0030054 IDA     early endosome membrane GO:0031901 IEA     ruffle membrane GO:0032587 ISS     intracellular membrane-bounded organelle GO:0043231 IBA     glial cell projection GO:0097386 ISS