Gene description for CEL
Gene name carboxyl ester lipase
Gene symbol CEL
Other names/aliases BAL
BSDL
BSSL
CELL
CEase
FAP
FAPP
LIPA
MODY8
Species Homo sapiens
 Database cross references - CEL
ExoCarta ExoCarta_1056
Entrez Gene 1056
HGNC 1848
MIM 114840
 CEL identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
Breast milk 17641064    
Colorectal cancer cells 25890246    
 Gene ontology annotations for CEL
Molecular Function
    hydrolase activity GO:0016787 TAS
    heparin binding GO:0008201 NAS
    protein binding GO:0005515 IPI
    carboxylic ester hydrolase activity GO:0052689 IBA
    catalytic activity GO:0003824 TAS
    triglyceride lipase activity GO:0004806 NAS
    acylglycerol lipase activity GO:0047372 TAS
    sterol esterase activity GO:0004771 TAS
Biological Process
    intestinal cholesterol absorption GO:0030299 NAS
    lipid digestion GO:0044241 TAS
    lipid metabolic process GO:0006629 NAS
    small molecule metabolic process GO:0044281 TAS
    protein esterification GO:0018350 NAS
    intestinal lipid catabolic process GO:0044258 NAS
    cholesterol catabolic process GO:0006707 NAS
    triglyceride metabolic process GO:0006641 IC
    pancreatic juice secretion GO:0030157 IDA
    fatty acid catabolic process GO:0009062 NAS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CEL in exosomes
1
Experiment ID 46
ISEV standards
EM|IEM
EV Biophysical techniques
HSC70
EV Cytosolic markers
CD63|MHCII|CD81|CD86
EV Membrane markers
CANX
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 48
ISEV standards
EM|IEM
EV Biophysical techniques
HSC70
EV Cytosolic markers
CD63|CD86|MHCII
EV Membrane markers
CANX
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
3
Experiment ID 286
ISEV standards
CEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81|EpCAM
EV Membrane markers
EV Negative markers
DLS
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CEL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CEL is involved
No pathways found





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