Gene description for OLR1
Gene name oxidized low density lipoprotein (lectin-like) receptor 1
Gene symbol OLR1
Other names/aliases CLEC8A
LOX1
LOXIN
SCARE1
SLOX1
Species Homo sapiens
 Database cross references - OLR1
ExoCarta ExoCarta_4973
Entrez Gene 4973
HGNC 8133
MIM 602601
UniProt P78380  
 OLR1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for OLR1
Molecular Function
    carbohydrate binding GO:0030246 IEA
    protein binding GO:0005515 IPI
    low-density lipoprotein receptor activity GO:0005041 IEA
Biological Process
    receptor-mediated endocytosis GO:0006898 IEA
    leukocyte migration GO:0050900 TAS
    inflammatory response GO:0006954 IEA
    lipoprotein metabolic process GO:0042157 IEA
    blood circulation GO:0008015 TAS
    blood coagulation GO:0007596 TAS
    cell death GO:0008219 IEA
    proteolysis GO:0006508 TAS
    response to hydrogen peroxide GO:0042542 IEA
    leukocyte cell-cell adhesion GO:0007159 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    receptor complex GO:0043235 IDA
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    membrane raft GO:0045121 IEA
    nucleoplasm GO:0005654 IDA
    membrane GO:0016020 TAS
 Experiment description of studies that identified OLR1 in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OLR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OLR1 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome





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