Gene description for U2af1
Gene name U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
Gene symbol U2af1
Other names/aliases 2010107D16Rik
35kDa
Species Mus musculus
 Database cross references - U2af1
ExoCarta ExoCarta_108121
Entrez Gene 108121
UniProt Q9D883  
 U2af1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for U2af1
Molecular Function
    nucleotide binding GO:0000166 IEA
    RS domain binding GO:0050733 IPI
    RNA binding GO:0003723 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    nucleic acid binding GO:0003676 IEA
Biological Process
    RNA splicing GO:0008380 IEA
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nuclear speck GO:0016607 IDA
    spliceosomal complex GO:0005681 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified U2af1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for U2af1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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