Gene description for CFHR3
Gene name complement factor H-related 3
Gene symbol CFHR3
Other names/aliases CFHL3
DOWN16
FHR-3
FHR3
HLF4
Species Homo sapiens
 Database cross references - CFHR3
ExoCarta ExoCarta_10878
Vesiclepedia VP_10878
Entrez Gene 10878
HGNC 16980
MIM 605336
UniProt Q02985  
 CFHR3 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CFHR3
Molecular Function
    complement component C3b binding GO:0001851 IBA
    protein binding GO:0005515 IPI
Biological Process
    complement activation GO:0006956 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified CFHR3 in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CFHR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CFH 3075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TPM2 7169
Affinity Capture-MS Homo sapiens
3 C3 718
Reconstituted Complex Homo sapiens
4 PRDX4 10549
Two-hybrid Homo sapiens
5 PRKCA 5578
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CFHR3 is involved
PathwayEvidenceSource
Complement cascade TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Regulation of Complement cascade TAS Reactome





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