Gene description for Cyb5r3
Gene name cytochrome b5 reductase 3
Gene symbol Cyb5r3
Other names/aliases 0610016L08Rik
2500002N19Rik
C85115
Dia-1
Dia1
WU:AL591952.1-001
WU:AL591952.1-002
WU:AL591952.1-003
WU:Cyb5r3
Species Mus musculus
 Database cross references - Cyb5r3
ExoCarta ExoCarta_109754
Entrez Gene 109754
UniProt Q9DCN2  
 Cyb5r3 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Cyb5r3
Molecular Function
    NAD binding GO:0051287 ISO
    ADP binding GO:0043531 ISO
    flavin adenine dinucleotide binding GO:0050660 ISO
    oxidoreductase activity GO:0016491 IEA
    AMP binding GO:0016208 ISO
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 ISO
    protein binding GO:0005515 IPI
Biological Process
    cholesterol biosynthetic process GO:0006695 IEA
    steroid metabolic process GO:0008202 IEA
    oxidation-reduction process GO:0055114 ISO
    cholesterol metabolic process GO:0008203 IEA
    steroid biosynthetic process GO:0006694 IEA
    sterol biosynthetic process GO:0016126 IEA
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 IEA
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrion GO:0005739 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum GO:0005783 IEA
 Experiment description of studies that identified Cyb5r3 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cyb5r3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyb5r3 is involved
PathwayEvidenceSource
Vitamin C (ascorbate) metabolism IEA Reactome





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