Gene description for Asl
Gene name argininosuccinate lyase
Gene symbol Asl
Other names/aliases 2510006M18Rik
Species Mus musculus
 Database cross references - Asl
ExoCarta ExoCarta_109900
Vesiclepedia VP_109900
Entrez Gene 109900
UniProt Q91YI0  
 Asl identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Asl
Molecular Function
    argininosuccinate lyase activity GO:0004056 ISO
    lyase activity GO:0016829 IEA
    catalytic activity GO:0003824 IEA
Biological Process
    urea cycle GO:0000050 ISO
    ammonia assimilation cycle GO:0019676 IMP
    cellular amino acid metabolic process GO:0006520 IMP
    arginine biosynthetic process via ornithine GO:0042450 IEA
    argininosuccinate metabolic process GO:0000053 ISO
    arginine biosynthetic process GO:0006526 IEA
    liver development GO:0001889 ISO
    locomotory behavior GO:0007626 IMP
    post-embryonic development GO:0009791 IMP
    internal protein amino acid acetylation GO:0006475 ISO
    cellular amino acid biosynthetic process GO:0008652 IEA
Subcellular Localization
    neuronal cell body GO:0043025 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    mitochondrial outer membrane GO:0005741 ISO
    extracellular exosome GO:0070062 ISO
    cell body fiber GO:0070852 ISO
    perikaryon GO:0043204 ISO
    endoplasmic reticulum GO:0005783 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Asl in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Asl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Asl is involved
PathwayEvidenceSource
Urea cycle IEA Reactome





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